SNS-595 Hydrochloride

Name	Voreloxin (Hydrochloride)
Synonyms	SNS-595 HYDROCHLORIDE AG 7352 Hydrochloride SNS-595 Hydrochloride AG 7352 HYDROCHLORIDE Vosaroxin Hydrochloride Voreloxin (SNS-595) HCl VOSAROXIN HYDROCHLORIDE Voreloxin (Hydrochloride) Voreloxin(SNS-595)hydrochloride (3S-trans)-1,4-Dihydro-7-[3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid monohydrochloride
CAS	175519-16-1

Molecular Formula	C18H20ClN5O4S
Molar Mass	437.9
Solubility	10 mM in DMSO
Storage Condition	-20℃
In vitro study	Voreloxin was able to effectively inhibit topoisomerase II relaxation with an IC50 of 3.2 μg/ml without affecting topoisomerase II cleavage. The cytotoxicity of Voreloxin against human tumor cell lines was more potent than that of etoposide. Voreloxin has broad antiproliferative activity against 15 cell lines, including 4 resistant cell lines, with an IC50 ranging from 0.04 to 1.155 μm.
In vivo study	Voreloxin (50 mg/kg, I. P.) showed potent antitumor activity in mice implanted with P388 leukemia cells. In 10 (breast, ovarian, colon, lung, gastric, and melanin) xenograft models of 11 solid tumor species, 2 hematologic tumor xenograft models, voreloxin (25 mg/kg, I. V.) in 3 multidrug-resistant tumor models and 3 mouse homologous tumor xenograft models (colon 26,Lewis lung carcinoma, M5076 ovarian sarcoma) indicates strong tumor growth inhibition.

Last Update：2024-01-02 23:10:35

Product Name: Voreloxin (Hydrochloride) Visit Supplier Webpage Request for quotation
CAS: 175519-16-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Product Name: Voreloxin (Hydrochloride) Visit Supplier Webpage Request for quotation
CAS: 175519-16-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

SNS-595 Hydrochloride

SNS-595 Hydrochloride Request for Quotation